Computational Analysis of HIV-1 Protease Protein Binding Pockets
نویسندگان
چکیده
منابع مشابه
Computational Analysis of HIV-1 Protease Protein Binding Pockets
Mutations that arise in HIV-1 protease after exposure to various HIV-1 protease inhibitors have proved to be a difficult aspect in the treatment of HIV. Mutations in the binding pocket of the protease can prevent the protease inhibitor from binding to the protein effectively. In the present study, the crystal structures of 68 HIV-1 proteases complexed with one of the nine FDA approved protease ...
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ژورنال
عنوان ژورنال: Journal of Chemical Information and Modeling
سال: 2010
ISSN: 1549-9596,1549-960X
DOI: 10.1021/ci100200u